Lynch Syndrome

New cancers linked with Lynch syndrome, study finds

June 11, 2018 - 12:48 pm

KYW’s Medical Reports Sponsored By Independence Blue Cross. 

By Dr. Brian McDonough, Medical Editor

PHILADELPHIA (KYW Newsradio) -- Lynch syndrome is a hereditary condition that has been associated with colorectal and endometrial cancer, but according to a new study looking at genetic analysis, only half of the cancers with lynch syndrome abnormalities were colorectal or endometrial cancer. 

Lynch syndrome was recognized in tumors rarely or not previously associated with the syndrome -- prostate, sarcoma or muscular, mesothelioma, and even some rare forms of ovarian cancer. 

With the ongoing emergence of precision medicine, more patients with cancer are being tested for MSI to determine whether their tumors can be matched to FDA-approved therapy. 

There are two major take away messages from this study. First, testing for lynch syndrome is a very important part of genetic screening. And the more we learn about cancer with nationwide studies, the more we can have an impact on screening.